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KMID : 0374019920150040303
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Ewha Medical Journal
1992 Volume.15 No. 4 p.303 ~ p.308
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Chromosomal Abnormalities in Patients with Hemato-Oncologic Diseases
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Abstract
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With development of new technology such as banding technique and high resolution banding technique. Cytogenetic examination has been utilized greatly in diagnosis and treatment of patients with hemato-oncologic diseases.
Forty two patients with newly diagnosed and previously untreated hemato-oncologic diseases were examined for chromosomal abnormalities which included 11 cases of acute myelogenous leukemia(AML). 7 cases of acute lymphoblastic leukemia(ALL) and
myelodysplastic syndrome (MDS) each. 6 cases of chronic myelogenous leukemia(CML), 5 cases of other myeloproliferative disorders(MPD). 4 cases of non-Hodgkin's lymphoma(NHL). and 1 case each of aplastic anemia(AA) and malignant schwannoma(MS).
Two cases of AML(18.2%) showed 45 XO and aneuploidy. Four cases of ALL(55.5%) showed chromosomal abnormalities ; 3 cases with Philadelphia chromosome and 1 case with 45 XO.
Only one case of MDS(14.3%0 showed trisomy 8 and none of 3 cases which were converted to AML showed chromosomal abnormalities. Five cases of CML(83.3%) showed Philadelphia chromosome. Chromosomal abnormalities were not noted in cases of MPD. NHL.
AA and
MS.
Collective studies of chromosomal abnormalities in hemato-onclologic diseases should be investigated further.
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KEYWORD
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